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YU News

Albert Einstein College of Medicine Professor Dr. Vern Schramm Selected for American Chemical Society Award

Oct 27, 2005 -- Dr. Vern Schramm, Professor and Ruth Merns Chair of Biochemistry at the Albert Einstein College of Medicine of Yeshiva University, has been selected to receive the Repligen Award for 2006 from the Biological Chemistry Division of the American Chemical Society. The award, presented to individuals whose outstanding contributions help improve our understanding of the chemistry involved in biological processes, recognizes Dr. Schramm’s contributions to the field of mechanistic enzymology. A member of the Einstein faculty since 1987, Dr. Schramm is world-renowned for his research into the “transition-state structure” of enzyme-catalyzed reactions -- the shapes that reacting molecules assume when enzymes catalyze chemical reactions. As he describes it, “Enzymes govern virtually all of the chemical transformations necessary for biological life but can also influence cells to become cancerous. By knowing the transition-state structure of enzyme-catalyzed reactions, we can design powerful inhibitors that can block those enzymes from acting and thereby treat or prevent cancer and other diseases.” Two of the inhibitors designed by the Schramm laboratory have entered clinical trials. One shows promise for treating leukemia that does not respond to other therapy. The second is in clinical trials as a possible treatment for eventual application to autoimmune diseases such as psoriasis, rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disorders and for preventing tissue transplant rejection for organ transplantation. In more than 35 years as a researcher and academician, Dr. Schramm has received numerous honors recognizing his contributions to both research and teaching within the field of biochemistry. These include election as a Fellow of the American Association for the Advancement of Science, the Rudi Lemberg Award from the Australian Academy of Science, the George A Sowell Award for Excellence in Teaching from Temple University School of Medicine, and the Harry Eagle Award for Outstanding Basic Science Teaching from the Albert Einstein College of Medicine.