Jan Vijg Jan Vijg (left), PhD, chairman of genetics at Albert Einstein College of Medicine of Yeshiva University, will lead a study the impact of damage to DNA on aging and disease. The National Institutes of Health (NIH) has awarded a five-year, $11.2 million grant to the study. Research funded by this grant, and conducted by a consortium of scientists, could reveal the role of genome maintenance systems in delaying aging and will begin to explore novel interventions to maintain health in old age.

The research project will build on the consortium’s previous, internationally recognized work involving mice that undergo accelerated aging. This research has shown that interfering with the cellular processes responsible for DNA repair leads to what appears to be premature aging in these animals. These results indicate that accumulating DNA errors may underpin the aging process.

The investigators in the consortium now plan to see if treatments based on these results can extend life spans of mice bred to have short lives. Read more. 

 

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